A general screen of micronutrients may be of clinical value in the management of patients with potential nutritional deficiency such as patients with Crohn’s Disease and other malabsorptive conditions, patients on total parenteral nutrition, and individuals whose nutrition may be inadequate such as the elderly.
The constituent parts of a micronutrient screen are selenium, copper, zinc, and vitamins A, C, & E (also includes vitamins D and K in Scotland) in plasma; manganese and vitamin B1 in whole blood; and selenium and vitamins B2, and B6 in red cells.
Sample Requirements for Micronutrient Screen
|Samples||One whole blood and one plasma/serum. Patient should be fasting and blood taken at least 8 hours post supplementation.|
Whole blood: Lithium heparin (non-gel) or EDTA (if suitable for trace elements).
Plasma/serum: Suitable for trace elements. SST/EDTA/Lithium heparin gel unsuitable.
Send one whole blood sample and plasma/serum from the other whole blood (to arrive within 48 hours of collection).
5 mL* whole blood
2 mL* plasma
650 µL* stabilised plasma for vitamin C
|Reference ranges||See details in specific micronutrient pages.|
|Mean turnaround time||4.5 days|
Vitamins by HPLC with UV, fluorimetric or electrochemical detection (except vitamin D which is measured by immunoassay).
Copper, zinc, selenium and manganese by inductively coupled plasma mass spectrometry.
* Absolute minimum volume; this volume is insufficient to carry out repeat analysis if analysis fails.